J00-J99 I00-I99
Conditions
Interventions
Group 1: The data collection will take place over the expected 24-month study period in the anesthesiology intensive care units at Heidelberg University Hospital. The recovery room and E99. Ventilatio
Sponsors
Universitätsklinikum Heidelberg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Indication for admission to an intensive care unit - Mechanically ventilated patients - Hypoxaemic respiratory failure, defined as PaO2/FiO2 ratio = 300 mmHg with invasive or non-invasive ventilation with PEEP = 5 mbar
Exclusion criteria
Exclusion criteria: - Age under 18 years - Pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The retrospectively created algorithms can be personalised using prospectively collected clinical patient data. 2. The pathophysiological characteristics of ARDS can be described using digital biomarkers and correlate with clinical endpoints. The evaluation of the primary endpoints is carried out after 80 patients have been included | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. digital biomarkers can predict clinical effects of a change in ventilation parameters. 2. in silico intervention tests in a protected software environment “sandbox” can show that the personalized algorithms support the adjustment of mechanical ventilation. 3. physical simulations can reproduce temporal drift and latent dynamics in airway disease, taking into account the biomechanical properties of the lung. The evaluation of secondary endpoints will be performed after 80 included patients | — |
Countries
Germany
Contacts
Public ContactJan Larmann
Universitätsklinikum Heidelberg
Outcome results
None listed