F40 F31 F32 F25 F20 F23 F33 F41 F42 F90 F84.5
Conditions
Interventions
Group 1: The following groups of patients will included (each n = 100) after screening under inpatient or outpatient treatment at the LVR-Klinikum Düsseldorf. Measurements at baseline with follow-up a
ICD-10 G35.1x) and
2. Patients with autoimmune encephalitis (AIE
ICD-10 G04.8) as immune-inflammatory control
3. Patients with somatoform disorders (ICD-10 F45.x) as non-inflammatory control
Routine data collection during clinical treatment:
• Blood and cerebrospi
Sponsors
LVR-Klinikum Düsseldorf
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: Adult patients who are being treated on an outpatient or inpatient basis in the Department of General Psychiatry 2 at the LVR Clinic Düsseldorf due to an underlying psychiatric illness. The following patient groups should be included: 1. Patients with affective disorders (ICD-10 F3x e.g. depression, bipolar affective disorder) 2. Patients with neurotic, stress and somatoform disorders (ICD-10 F4x e.g. anxiety disorders, obsessive compulsive disorders) 3. Patients with schizophrenia, schizotypal and delusional disorders (ICD-10 F2x e.g. schizophrenia) 4. Patients with developmental disorders (ICD-10 F8x e.g. autism spectrum disorder) 5. Patients with behavioral and emotional disorders that began in childhood and adolescence (ICD-10 F9x, e.g. simple activity and attention disorder) Adult patients with the following illnesses who are treated on an outpatient or inpatient basis in the Department of Neurology at the University Hospital Düsseldorf: 1. Patients with relapsing-remitting multiple sclerosis (RRMS; ICD-10 G35.1x) and 2. patients with autoimmune encephalitis (AIE; ICD-10 G04.8) as an immune-inflammatory control cohort and 3. patients with somatoform disorder (ICD-10 F45.x) as a non-immune-inflammatory control cohort.
Exclusion criteria
Exclusion criteria: Exclusion criteria: • Pregnant or breastfeeding women • People < 18 years of age • Patients unable to give consent, with the exception of patients under legal guardianship, where the patient and guardian give informed consent. • Patients with contraindications for MRI and MEG examinations, e.g. due to pacemaker implants • Previous treatment with immunosuppressants, including chemotherapy, whole-body irradiation or bone marrow transplantation • Treatment with high doses of steroids, immunoadsorption/plasmapheresis or immunoglobulins within 3 months prior to sampling • Ongoing treatment with immunosuppressants including chemotherapy, steroids, immunoadsorption/plasmapheresis, immunoglobulins or whole-body irradiation at the time of sampling • Patients with other systemic inflammatory diseases (e.g. systemic lupus erythematosus, systemic vasculitis) • Patients with immune deficiencies • Obvious signs of a systemic infection or known acute or chronic infectious diseases (e.g. HIV, HBV/HCV, TB) • History of drug use in the last 14 days prior to examination (drug urine test in urine is routinely performed as part of psychiatric treatment and thus before inclusion)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| What is the connection between the immune system and social interaction in neuropsychiatric diseases? | — |
Secondary
| Measure | Time frame |
|---|---|
| What conclusions can be drawn for diagnosis and therapy? | — |
Countries
Germany
Contacts
Public ContactTimo Jendrik Faustmann
LVR-Klinikum Düsseldorf
Outcome results
None listed