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Clinical analysis of the influence of a combination of biomaterials with autologous fibrin matrix (PRF) on wound healing and bone regeneration after osteotomy of displaced and retained wisdom teeth; a prospective, randomized clinical study in split-mouth design.

Clinical analysis of the influence of a combination of biomaterials with autologous fibrin matrix (PRF) on wound healing and bone regeneration after osteotomy of displaced and retained wisdom teeth; a prospective, randomized clinical study in split-mouth design.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00036122
Enrollment
180
Registered
2025-02-07
Start date
2024-06-10
Completion date
Unknown
Last updated
2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

K08.1

Interventions

Group 1: PRF solid vs. allogen bone substitute material w/PRF - preservation of the extraction socket according to randomization in split mouth design with solid PRF on one side and contralateral w/ c

Sponsors

Universitätsklinikum der Goethe-Universität Frankfurt am Main Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients in need of osteotomy of at least two third molars (at least 1 tooth on each side); - Patients with informed consent (under age patients with parents approval); Patients at an age of at least 16 years

Exclusion criteria

Exclusion criteria: - Patients younger than 16 years; - Patients with contraindication for surgery; -Patients allergic to necessary medication and/or medical devices; -Patients with chronic medication possibly influencing pain perception and/or inflammation and/or wound healing ; -Immunocompromised persons; - Patients without informed consent; -Pregnant or breast feeding women

Design outcomes

Primary

MeasureTime frame
- Swelling according to Gabka+Matsumara, measured between 5 reference points - Preservation of bone structure 6 months post extraction (radiological evaluation)—

Secondary

MeasureTime frame
- pain (VAS) - wound healing and morbidity - trismus (maximal mouth opening) - post-surgery complications - photo documentation of wound healing—

Countries

Germany

Contacts

Public ContactShahram Ghanaati

Universitätsklinikum der Goethe-Universität Frankfurt am Main Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie

Studienzentrale-MKPG@unimedizin-ffm.de+49-69-6301-4492

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026