G40
Conditions
Interventions
Group 1: Examination of patients with epilepsy: Each study participant is measured on a 3T MRI and a 7T MRI within a maximum of two consecutive days. Both scanners are located at the Cooperative Brain
Sponsors
Universitätsklinikum Frankfurt, Institut für Neuroradiologie
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers (no neurological diseases), epilepsy patients with diagnosed epilepsy
Exclusion criteria
Exclusion criteria: Previous brain surgery, medication that affects the release of neurotransmitters, active drug or alcohol addiction, pregnancy or breastfeeding, mental illness that could affect participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the accuracy of the concentration measurement of Gamma-aminobutyric acid (GABA) and glutamate in healthy volunteers and epilepsy patients using MRS at 3 Tesla (T) compared to 7T. | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) Explorative comparison of the concentrations of GABA and glutamate in epilepsy patients compared to a healthy age-matched control group; (2) Explorative comparison of the concentrations of GABA and glutamate in epilepsy patients with biopsy-proven limbic encephalitis and positive antibody detection against glutamate decarboxylase (GAD) or GABAA/B receptors in the amygdala compared to a healthy age-matched control collective. | — |
Countries
Germany
Contacts
Public ContactElke Hattingen
Universitätsklinikum Frankfurt, Institut für Neuroradiologie
Outcome results
None listed