Comparison of different loading protocols after intra-articular corticosteroid injection (IACSI) to the lower extremity in juvenile idiopathic arthritis (JIA) - A multicenter prospective registry of the Society for Pediatric and Adolescent Rheumatology (GKJR)

Comparison of different loading protocols after intra-articular corticosteroid injection (IACSI) to the lower extremity in juvenile idiopathic arthritis (JIA) - A multicenter prospective registry of the Society for Pediatric and Adolescent Rheumatology (GKJR) - RIANa - Registry for IACSI post-treatment protocols for gonarthritis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00036083

Enrollment

Registered

2025-02-17

Start date

2025-03-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M08.0 M08.3 M08.4

Interventions

Group 1: Each participating center pursues different post-treatment strategies. Two different stress groups were identified through survey results. Each center sticks to its own treatment procedure, w

Eligibility

Sex/Gender

All

Age

6 Years to 18 Years

Inclusion criteria

Inclusion criteria: - Diagnosis of JIA, oligo- or polyarthritis category according to ILAR criteria - Therapeutic use of forearm crutches and/or therapy rollers possible - IACSI knee - Consent

Exclusion criteria

Exclusion criteria: - Additional IACSI on other joints of the lower extremity (ankle/hip) - Cortisone shock treatment within four weeks before/after the procedure - Bony damage to the joint - Surgery on the knee - Lack of understanding

Design outcomes

Primary

Measure	Time frame
'Time to flare' or time period until thrust. A flare is defined as evidence of of fluid or signs of inflammation (painful restriction of movement or effusion) more than two weeks after the intra-articular corticosteroid injection (IACSI), after the signs of inflammation have completely subsided in the meantime. By means of sonography (evaluation according to OMERACT criteria) to detect an effusion, pain by means of a visual analog scale (VAS), range of motion of the knee joint/range of motion (ROM) by means of a goniometer at the following measurement times: T0: before IACSI T1: 12-20 weeks after IACSI T2: 40-60 weeks after IACSI And, if necessary, at further measurement times if interim examinations are required due to medical necessity (recurrence of pain, swelling, movement restrictions) outside the set time windows of T1 and T2.	—

Measure

Time frame

'Time to flare' or time period until thrust. A flare is defined as evidence of of fluid or signs of inflammation (painful restriction of movement or effusion) more than two weeks after the intra-articular corticosteroid injection (IACSI), after the signs of inflammation have completely subsided in the meantime. By means of sonography (evaluation according to OMERACT criteria) to detect an effusion, pain by means of a visual analog scale (VAS), range of motion of the knee joint/range of motion (ROM) by means of a goniometer at the following measurement times: T0: before IACSI T1: 12-20 weeks after IACSI T2: 40-60 weeks after IACSI And, if necessary, at further measurement times if interim examinations are required due to medical necessity (recurrence of pain, swelling, movement restrictions) outside the set time windows of T1 and T2.

—

Secondary

Measure	Time frame
- Range of motion knee joint (goniometer) - Swelling/knee circumference measurement (measuring tape) - Stiffness (Visual Analog Scale (VAS)) - Walking speed (50ft) - Pain (VAS) - Findings of knee joint sonography (assessment according to OMERACT criteria) at the following measurement times: T0: before IACSI T1: 12-20 weeks after IACSI T2: 40-60 weeks after IACSI And, if necessary, at further measurement times if interim examinations are required due to medical necessity (recurrence of pain, swelling, movement restrictions) outside the set time windows of T1 and T2.	—

Measure

Time frame

- Range of motion knee joint (goniometer) - Swelling/knee circumference measurement (measuring tape) - Stiffness (Visual Analog Scale (VAS)) - Walking speed (50ft) - Pain (VAS) - Findings of knee joint sonography (assessment according to OMERACT criteria) at the following measurement times: T0: before IACSI T1: 12-20 weeks after IACSI T2: 40-60 weeks after IACSI And, if necessary, at further measurement times if interim examinations are required due to medical necessity (recurrence of pain, swelling, movement restrictions) outside the set time windows of T1 and T2.

—

Countries

Germany

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 10, 2026