Healthy subjects
Conditions
Interventions
Group 1: 1.8 g black pepper per day p.o. (consumed with rice), 14 days
Group 2: 1.8 g placebo per day p.o. (consumed with rice), 14 days
Sponsors
Technical University of Munich, ZIEL - Institute for Food and Health, TUM School of Life Sciences Weihenstephan
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Written declaration of consent; Omnivorous, pescatarian, vegetarian or vegan diet
Exclusion criteria
Exclusion criteria: Missing declaration of consent; Current participation in another intervention trial; Body mass index under 18.5 or above 30 kg/m2; Pregnancy or breastfeeding; Known allergies or intolerance to different peppers (black pepper, green pepper, white pepper), rice (white rice, black rice), brilliant blue FCF (E 133) or other ingredients in the test foods; Known allergies to other foods with cross-reactivities with rice: other cereals (barley, oats, wheat, rye, corn, triticale, spelt), fruits and vegetables (peaches, citrus fruits, grapes, toma-toes, asparagus, lettuce, onions, carrots), nuts (hazelnuts, walnuts, peanuts), soybean, grass pollen; Antibiotic treatment in the 6 months prior to the start of the study; Diverticulitis; Acute gastrointestinal disorders or bleeding disorders; Planned surgeries during the trial; Prescription medications (eg. anticoagulants, antihyperlipidemic drugs); High dose supplements (eg. piperine, fibers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In this study, the primary endpoint is the change in the gut microbiota composition of the participants after consuming black pepper. Stool samples collected before and after black pepper consumption are analyzed using high-throughput sequencing to examine the microbiota composition. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary endpoint is the influence of black pepper consumption on the metabolite profile in the intestine and blood of the participants. Both stool and blood samples are collected before and after black pepper consumption, and are analyzed using metabolomics methods for metabolite profiles. | — |
Countries
Germany
Contacts
Public ContactShengcheng Ren
Technical University of Munich, ZIEL - Institute for Food & Health, Chair of Nutrition and Immunology
Outcome results
None listed