Induction of Inflammation
Conditions
Interventions
Group 1: 45 minutes of downhill running (12% gradient) at 70% of VO2max followed by 3 hours of taVNS stimulation (Cymba Conchae)
Group 2: 45 minutes of downhill running (12% gradient) at 70% of VO2max
Sponsors
Justus-Liebig-Universität Gießen, Abteilung für Leistungsphysiologie
Eligibility
Sex/Gender
Male
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: o Physically, neurologically and mentally healthy participants o No intake of psychotropic medication o Confirmed fitness for sport
Exclusion criteria
Exclusion criteria: o Acute/chronic psychiatric, immunological or neurological diseases o More than 4 hours of endurance sport per week o Regular intake of medication with psychotropic or immunological effects o Smokers o No confirmed fitness for sport at the first appointment o Open wounds on the ear o Skin diseases on the ear o People with active implants (e.g. cochlear implant, pacemaker) o People with cerebral shunt
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heartratevariability (HRV) with average RR duration, average heartrate, Standard-Deviation of RR-Intervall (SDNN), Root Mean Sum of Squared Distance (RMSSD), PNN50 | — |
Secondary
| Measure | Time frame |
|---|---|
| serum cytokines: IL6, IL8, IL10, TNFalpha, CK, CRP, S100A8, Myoglobin, PBMCs (peripheral blood mononuclear cells), CD3, CD4, and CD8 T cells, Respirometry of PBMCs, transcriptomics, proteomics, ATP, reactive Oxygenspecies (ROS) | — |
Countries
Germany
Contacts
Public ContactKristina Gebhardt
Justus-Liebig-Universität Gießen, Abteilung für Leistungsphysiologie
Outcome results
None listed