Cleaning of intensive care units with probiotics and its effect on the acquisition of Pseudomonas aeruginosa in blood cultures and tracheal aspirates – an interrupted time-series analysis

Cleaning of intensive care units with probiotics and its effect on the acquisition of Pseudomonas aeruginosa in blood cultures and tracheal aspirates – an interrupted time-series analysis - CLINO

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00036014

Enrollment

19154

Registered

2025-02-10

Start date

2022-12-01

Completion date

Unknown

Last updated

2026-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU-acquired Pseudomonas aeruginosa in blood cultures and tracheal aspirates ICU-acquired MDRO detected in screening or clinical samples. MDRO were defined as MRSA, vancomycin-resistant Enterococcus faecium / Enterococcus faecalis (VRE) or multidrug-resistant Gram-negative bacteria (MDRGN). B96.5

Interventions

Group 1: Intervention: Daily routine cleaning of surfaces in intensive care units with probiotic detergent (Synbio by HeiQ/Chrisal, concentrated 1%, with detergents and prebiotics (inulin), Bacillus

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Stay on study ward (intensive care unit)

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
Incidence (density) of intensive care unit-acquired Pseudomonas aeruginosa in blood cultures and tracheobronchial aspirate / sputum on the basis of routine microbiological findings from clinical examinations (routine diagnostics)	—

Secondary

Measure	Time frame
Incidence (density) of intensive care unit-acquired (colonization and infection) of multi-drug-resistant organisms (MDRO) including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), multidrug-resistant gram-negative bacteria (MRGN) on the basis of routine microbiological findings from screening and clinical examinations (routine diagnostics)	—

Countries

Germany

Contacts

Public ContactLuisa Denkel

Institut für Hygiene und Umweltmedizin Berlin

luisa.denkel@charite.de+49 30 450 577 612

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026