C44
Conditions
Interventions
Group 1: Wound cover with Geistlich Mucograft(R) in combination with autologous blood concentrate (= treatment group)
Group 2: Wound cover with Geistlich Mucograft(R) alone (= control group)
Sponsors
Universitätsklinikum der Goethe-Universität Frankfurt | Fachbereich Medizin Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Subjects >/= 18 years in good health - Basal cell carcinoma (BCC) indication in the head and neck facial area - Indication for excision and defect coverage by means of collagen membrane - Subjects capable of consenting and who have agreed to the inclusion and participation in the study - Patients who are able to follow treatment- and study-related guidelines
Exclusion criteria
Exclusion criteria: - Defect size after excision exceeds the possibility of defect coverage by means of collagen membrane - Allergy to collagen - Corticosteroid intake - ongoing or already completed chemotherapy - ongoing or already completed radiation therapy - Infectious diseases - General medical contraindications with regard to blood sampling - No vulnerable groups/minors - Pregnant and breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Healing process based on clinical photo documentation - POSAS questionnaire on wound quality and patient satisfaction | — |
Secondary
| Measure | Time frame |
|---|---|
| Stimulation of neutrophilic granulocytes for differentiation into the regenerative phenotype, detectible by the release of MMP8 in wound exudate | — |
Countries
Germany
Contacts
Public ContactShahram Ghanaati
Klinik für Mund-, Kiefer- und Plastische Gesichtschirurgie, Universitätsklinikum der Goethe-Universität, Frankfurt am Main
Outcome results
None listed