C67
Conditions
Interventions
Group 1: 20 patients with muscle-invasive bladder carcinoma scheduled for radical cystectomy with ISAR score = 2 points or characteristic for multimorbidity (according to the definition of the German
Sponsors
Deutsche Rentenversicherung Hessen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients with a diagnosis of a muscle-invasive malignancy of the urinary bladder (urothelial carcinoma or other histological variants) or a non-muscle-invasive high-risk malignancy of the urinary bladder with an oncological indication for radical cystectomy in accordance with the current S3 guideline [1,2]. - Planned cystectomy at the University Hospital Marburg or Giessen. - ECOG (Eastern Cooperative Oncology Group) performance status of = 2 [35] - =3 weeks until radical cystectomy - Sufficient German language skills - Signed written informed consent form - 3 Criteria for patients with an increased risk of complications are examined exploratively: - 1. patients aged = 65 years and an ISAR score = 2 points [34] - 2. patients who are either =80 years or =70 years old and have at least 1 geriatric characteristic for multimorbidity (according to the definition of the German Society for Geriatrics): - Immobility, tendency to fall and dizziness, - cognitive deficits, depression, anxiety disorder - Incontinence (urinary incontinence, rarely fecal incontinence), - Decubitus ulcers, - malnutrition, - disorders of fluid and electrolyte balance, - chronic pain, - sensory disturbances, - reduced physical resilience/frailty, - severe visual impairment, pronounced hearing loss, - recurrent infections, reduced immunocompetence, - multiple medication - Reduced tolerance to medication - frequent hospital stays (revolving door effect). - 3. patients with a score from the American Society of Anesthesiologists physical status classification (ASA) score of 3 or higher.
Exclusion criteria
Exclusion criteria: - Time to surgery < 3 weeks. - Patients with comorbidities or diseases that preclude participation in the exclude participation in the planned training program: - heart failure NYHA IV - Severe pain with or without performing the exercises - Inability to stand or sit independently - Maximum walking time of <6 minutes. - Severe cognitive impairment, assessed by 1. the inability to perform the exercises required for the inclusion examination exercises (walking distance test, short physical performance battery, hand strength test) on instruction. 2. the inability to consent to participation in the study. - Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of the study program measured by recruitment, acceptability (Acceptability E-Scale), adherence (logbook). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Physical condition and performance (6-minute walking distance, hand strength test, Short Physical Performance Battery) - Therapy safety - Quality of life (EORTC-QLQ-C30) - Depression and anxiety (PHQ-4) - Postoperative complications | — |
Countries
Germany
Contacts
Public ContactChrister Groeben
Klinik für Urologie, Philipps-Universität Marburg
Outcome results
None listed