Influence of enamel matrix proteins and hyaluronic acid on periodontal regeneration in intrabony defects - a prospective clinical intervention study ”

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00035818

Enrollment

Registered

2025-03-19

Start date

2025-01-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Persistent chronic periodontitis

Interventions

Group 1: Regenerative periodontitis therapy with enamel matrix proteins vs. hyaluronic acid with/without bone substitutes

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with pocket probing depths >6mm after anti-infective therapy for vertical 2- or 3-wall bone defects

Exclusion criteria

Exclusion criteria: Smokers > 6 cigarettes per day, diabetics with Hba1c value >8

Design outcomes

Primary

Measure	Time frame
The primary objective is to investigate the effectiveness of SMP and HA for periodontal regeneration in the treatment of intrabony 2 and 3-wall defects and class 2 furcations on molars. The parameters collected are to be statistically statistically compared with each other in a parallel study.	—

Secondary

Measure	Time frame
The radiological assessment of bony regeneration, the evaluation of postoperative wound healing and the collection of bleeding parameters will be examined as secondary endpoints.	—

Countries

Germany

Contacts

Public ContactPhilipp Grozinger

MVZ Kieferchirurgie Königsallee

dr.grozinger@mkg-praxis.com+492111360900

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026