K08
Conditions
Interventions
Group 1: Ibuprofen
In the study, patients are enrolled only after administering preemptive analgesia
the choice of medication is based on the preferences of the treating physician. Therefore, it is a non-interventional study.
Group 2: Etoricoxib
Group 3: No preemptive analgesia
Sponsors
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Consent obtained patients capable of providing informed consent aged between 18 and 65 years undergoing implant placement or tooth extraction under local anesthesia.
Exclusion criteria
Exclusion criteria: - **Analgesic intake within 24 hours prior to the procedure** - **Chronic or long-term analgesic use, or use of psychotropic medication** - **Conditions contraindicating the use of non-opioid analgesics**: These patients will not receive preemptive therapy (e.g., heart failure NYHA II–IV, coronary artery disease, peripheral arterial occlusive disease, cerebrovascular diseases, hypersensitivity to the active ingredient or tablet components, active peptic ulcer disease or gastrointestinal bleeding, history of bronchospasm, acute rhinitis, nasal mucosa swelling, angioedema, urticaria, or allergic symptoms following NSAID intake, severe hepatic impairment [caution required in mild to moderate hepatic impairment]). **Other conditions excluding preemptive administration of ibuprofen or etoricoxib**: - Renal insufficiency with an estimated creatinine clearance 65 years - Concurrent jawbone augmentation (e.g., guided bone regeneration) - Complex augmentations or sinus lift procedures - Placement of more than four implants - Simultaneous soft tissue graft harvesting (e.g., from the palate) - Simultaneous bone harvesting (e.g., using a bone scraper) - Concurrent tooth extraction (exception: immediate implantation) - Osteotomy of more than two teeth - Extraction of more than ten teeth
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain (VAS 1–10) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Intraoperative pain (VAS 1–10) 2. Intraoperative discomfort (VAS 1–10) 3. Time until the first onset of postoperative pain (hours) 4. Time until the first intake of analgesics (hours) 5. Overall pain duration exceeding 24 hours (yes/no) 6. Cumulative amount of postoperative analgesics consumed 7. Mid-term (7 days) oral health-related quality of life (OHIP-G 53). | — |
Countries
Germany
Contacts
Public ContactPeer Kämmerer
Universitätsmedizin der Johannes Gutenberg-Universität Mainz
Outcome results
None listed