Preeclampsia (PE), gestational diabetes mellitus (GDM), with or without obesity
Conditions
Interventions
Group 1: 1. Early/late-onset preeclampsia (PE) patients with- vs. without obesity.
2. Gestational diabetes Mellitus (GDM) patients with- vs. without obesity.
Sponsors
Uniklinikum Frankfurt , Frauenklinik, Haus 15
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Pregnant women, who are = 18 years old and not associated with chronic disease, will be enrolled in this study. The clinical team will be responsible for personally informing participants about this study and receiving their permission. Women, who agree, will be invited to take part in this study.
Exclusion criteria
Exclusion criteria: Pregnant women, who are under 18 years old, or have history of renal, liver or vascular disease, infection, classical diabetes mellitus (DM), and primary hypertension, will be excluded from this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A.Alterations in adipose tissue and blood in mother with obesity. B.Changes in the placenta from mother with obesity. C.Molecular mechanisms mediating maternal obesity to an increased gestational diseases, such as PE and GDM. | — |
Secondary
| Measure | Time frame |
|---|---|
| D. Main molecular causes leading to adverse short- and long-term outcomes in the offspring | — |
Countries
Germany
Contacts
Public ContactJuping Yuan
Geburtshilfe und Pränatalmedizin, Frauenklinik, Uniklinikum Frankfurt
Outcome results
None listed