Influence of cerebellar transcranial alternating current stimulation (tACS) on properties of gait in Parkinson's disease

Influence of cerebellar transcranial alternating current stimulation (tACS) on properties of gait in Parkinson's disease - Cerebellar stimulation and gait in Parkinson's disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035792

Enrollment

Registered

2025-02-07

Start date

2025-02-18

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson

Interventions

Group 1: Intervention group: Parkinson's patients tACS is applied during a) a 5-minute gait sequence and b) a stop-and-go task. Experimental conditions/intervention: 1) Sham stimulation 2) Stimulat

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria for Parkinson's patients - Parkinson's disease (according to British Brain Bank criteria: L-dopa sensitivity of at least 50%). - Hoehn and Yahr stage = 2.5. - Fluctuations and/or dyskinesias for no longer than 3 years. - Written informed consent. - Age (40-75 years). Inclusion criteria for healthy subjects - Written informed consent - Age is adapted to that of the patient cohort (checked by the investigator)

Exclusion criteria

Exclusion criteria: Exclusion criteria for Parkinson's patients - History of falls: > 1 fall in the last 12 months, only allow 1 fall in the last 12 months if other tests have shown no abnormalities (NFOGQ = 0; UPDRSIII item 3.10 = 0; UPDRSIII item 3.11 = 0; TUG =2 ("Patient walks without assistance, but with significant gait disturbance.") - Occurrence of dyskinesia - Other psychiatric or neurological diagnoses, organic brain disease or severe systemic disease that may affect the central nervous system - BMI>30 - Metal implants on the head and in the vicinity of the cervical spine (e.g. through deep brain stimulation, stiffening of the cervical spine, etc.) Exclusion criteria for healthy subjects - previous neurological diseases - gait disorders - Metal implants on the head and in the vicinity of the cervical spine

Design outcomes

Primary

Measure	Time frame
Phase-specific parameters for displaying the synchronization or entrainment of tACS and step frequency: phase synchronization index (PSI) Gait-specific parameters, such as the stride frequency, walking speed, stride length, Limb Symmetry Index (LSI)	—

Secondary

Measure	Time frame
EEG data UPDRS Teil 3 Subjective experiences and perceptions	—

Countries

Germany

Contacts

Public ContactMarc Varel

Johannes Gutenberg-Universität Mainz, Institut für Sportwissenschaft, Abteilung Sportpsychologie

mvarel@uni-mainz.de+4961313926402

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026