Study on healthy overweight subjects with increased BMI and body fat percentage, which is associated with an increased inflammatory status.
Conditions
Interventions
Group 1: Intervention group plant substance 40mg
Group 2: Intervention group plant substance 13mg
Group 3: Placebo group
Group 4: Healthy Control without intervention
Sponsors
Institut für Ernährungsmedizin, UKSH
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: - Weight: 70-130kg - BMI: 25-40kg/m² - Body fat percentage: men >25%, women >35% - Sufficient knowledge of German to understand the study documents and the procedure
Exclusion criteria
Exclusion criteria: - acute illness - Taking anti-inflammatory or immunosuppressive medication - Consumption of illegal substances - Diagnosed autoimmune disease that is treated with anti-inflammatory or immunomodulatory drugs - Pregnancy and breastfeeding - Implanted electronic device (pacemaker, defibrillator, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the change in biomarkers of inflammatory status in subjects with increased BMI and body fat percentage after 6 weeks of daily intake of a phytochemical. For this purpose, blood is taken and frozen on the start day of the study and after six weeks (end of study). All blood samples that have been frozen in the meantime will be analysed at the same time after all subjects have undergone the intervention. For example, the level of high-sensitivity (hs)-CRP in the blood before and after the study will be compared in order to check for an improvement in inflammatory status as a result of the plant substance. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determination of the bioavailability of the ingested plant substance in the blood on the start day of the study; 0, 1 and 1.5 hours after ingestion of the plant substance. | — |
Countries
Germany
Contacts
Public ContactMarc Ehlers
Institut für Ernährungsmedizin, UKSH
Outcome results
None listed