C43
Conditions
Interventions
Group 1: Healthy volunteers on whom deuterium magnetic resonance imaging (DMI) is to be performed (examination procedure: drinking of 250 ml glucose solution, after 15 min DMI of the head with differe
Sponsors
Max-Planck-Institut für biologische Kybernetik, Magnetresonanz Zentrum (MRZ) und Werner Reichardt Centrum für Integrative Neurowissenschaften (CIN), Tübingen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: For healthy subjects (Arm 1): • Consent For patients (Arm 2): • Consent • Stage IV melanoma with known brain tumor/brain metastasis • Brain tumor/brain metastasis > 1 cm • Brain tumor/brain metastasis with known contrast enhancement
Exclusion criteria
Exclusion criteria: For healthy subjects (Arm 1): • Contraindications to MRI examinations • Pregnancy • Unwillingness to be informed about incidental findings • History of diabetes mellitus or insulin resistance • Clinical evidence of electrolyte imbalance • History of malabsorption, extensive bowel resection or acute gastroenteritis. For patients (Arm 2): • Contraindications to MRI examinations • Pregnancy • Severe dysarthria/aphasia • Unwillingness to be informed about incidental findings • History of diabetes mellitus or insulin resistance • Clinical evidence of electrolyte imbalance • History of malabsorption, extensive bowel resection or acute gastroenteritis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of the DMI measurement protocol for patients with brain metastases: Validation and optimization of various MRI sequences based on image quality with regard to deuterium resonances | — |
Secondary
| Measure | Time frame |
|---|---|
| - Optimization of various MR measurement sequences - Establishment the measurement protocol with the aim of determining the known conversion rates of glucose using deuterium MR with spatial resolution and, if necessary, time resolution. - Determination of the influence of the amount of [6,6'-2H2]glucose administered on the measurable signal for cost estimation. | — |
Countries
Germany
Contacts
Public ContactJohannes Schwenck
Universitätsklinikum Tübingen, Radiologische Klinik, Nuklearmedizin & Molekulare Bildgebung
Outcome results
None listed