Corneal changes after application of hyperosmolar eye drops in patients with Fuchs' endothelial dystrophy

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035637

Enrollment

Registered

2025-03-21

Start date

2025-03-26

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

H18.5

Interventions

Group 1: patients with Fuchs' endothelial dystrophy (observation of diurnal changes) Group 2: patients with Fuchs' endothelial dystrophy (observation after application of hyperosmolar eye drops)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: understanding the consent form written consent moderate Fuchs' endothelial dystrophy (modified Krachmer grade >=3)

Exclusion criteria

Exclusion criteria: corneal pathology (except Fuchs' endothelial dystrophy) use of hyperosmolar, antiglaucoma or steroid eye drops 7 days before examination wear of contact lenses 7 days before examination previous eye surgery (except uncomplicated cataract-surgery > 3 months before examination) poor quality of measurements high myopia ( +10 dpt), high astigmatism (> 5 dpt) pregnancy, lactation

Design outcomes

Primary

Measure	Time frame
mean total corneal refractive power	—

Secondary

Measure	Time frame
corneal thickness, keratometry of front and back surface	—

Countries

Germany

Contacts

Public ContactCarolin Kolb-Wetterau

Universitätsmedizin Mainz

carolin.kolb-wetterau@unimedizin-mainz.de00496131170

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026