Q23.4
Conditions
Interventions
Group 1: Children und Adults with univentrikular heart and Fontan-palliation
Group 2: Patients with other congenital heart defects
Group 3: Children and adults without congenital heart defects
Sponsors
Klinikum der Universität München
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient group: Patients with the following criteria should be included in the study: - Patients with a univentricular heart and completed palliation according to the Fontan principle - There is no age limit, palliation according to the Fontan principle is usually completed from the age of two, but earlier or much later completion of Fontan palliation is also possible. Since children with Fontan circulation reach adulthood, adult subjects will also be included in the study. Control group: - Patients with other congenital heart defects who are matched to the study group in terms of gender and age. - Healthy patients, siblings if possible, or patients who are matched to the study group in terms of gender and age.
Exclusion criteria
Exclusion criteria: General: Lack of consent to participate in the study or withdrawal of consent - All subjects must be free of infection during the examination, as an infection has a proven effect on microcirculation. - For healthy control patients: They must not have any underlying cardiovascular disease, including all diseases that affect the cardiovascular system, e.g. diabetes mellitus, underlying oncological disease with a history of chemotherapy and neuromuscular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| By means of structural and functional examination, especially of the vascular endothelium, the detection of corresponding changes should contribute to the general understanding of the changes in Fontan palliation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Is there a connection between the above-mentioned measured values ??(point 1) and/or corresponding changes over time (point 2) and Fontan-specific clinical parameters (e.g. presence of a failing Fontan, hypoalbuminemia, Fontan-specific hemodynamic parameters) | — |
Countries
Germany
Contacts
Public ContactAndré Jakob
Klinikum der Universität München
Outcome results
None listed