O14.0
Conditions
Interventions
Group 1: HDP-Group
Pregnant patients with a diagnosis of HDP and/or associated complications. Complications include: Preeclampsia
HELLP syndrome
eclampsia
peripartum cardiomyopathy (PPCM)
thrombogenic microangiopathies (TMA) in pregnancy (a-HUS, TTP)
acute renal failure in pregnancy
posterior reversible encephalopathy syndrome (PRES).
Healthy control group:
Pregnant patients without associated pregnancy complications or pre-existing diseases of the cardiovascular system and gluc
Sponsors
Universitätsklinikum Giessen und Marburg- Standort Marburg, Klinik für Gynäkologie und Geburtshilfe
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Signed written informed consent Clinically confirmed diagnosis of HDP/associated complications Pregnant patients with a HDP/associated complication with a singleton pregnancy Healthy pregnant women with a singleton pregnancy > 37th week of pregnancy
Exclusion criteria
Exclusion criteria: Pregnant women < 18 years of age Non-pregnant female patient Smoking during pregnancy Multiple pregnancy Gestational diabetes Preexisting hypertension Preexisting nephrological/cardiological/endocrinological disease Premature rupture of membranes < 37th week of gestation (PPROM)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demonstration of the association between extreme weather events and high concentrations of air pollutants depending on the week of pregnancy and the development of hypertensive disorders in pregnancy (HDP) and associated complications (endpoints: morbidity and mortality of mother and child). - Does a worsening of hypertensive disorders/complications result from extreme weather events and/or high concentrations of air pollutants during pregnancy? | — |
Secondary
| Measure | Time frame |
|---|---|
| Maternal: Inpatient length of stay Psychological stress due to diagnosis Persistent cardiovasc. restriction (hypertension, LVEF, ECG) Neonatal: Prematurity: Transfer to neonatological intensive care unit. Weight at birth Development at the age of U4 The parameters are recorded from the following sources: 1. Patient file 2. Questionnaire: study inclusion and three months postpartum 3. Diagnostic imaging (ultrasound) – study inclusion and three months postpartum 4. Standardized questionnaire (Edinburgh Postnatal Depression Scale, EPDS) – study inclusion and three months postpartum | — |
Countries
Germany
Contacts
Public ContactCorinna Keil
Universitätsklinikum Giessen und Marburg, Standort Marburg- Klinik für Gynäkologie und Geburtshilfe
Outcome results
None listed