C00-C14 C32
Conditions
Interventions
Group 1: HNSCC group
These are patients with neoplasms in the head/neck area who undergo panendoscopy and biopsy to clarify the neoplasm in more detail. If a malignant disease becomes apparent, the p
Sponsors
Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who presented to the Departement of otolaryngology with suspected head and neck tumors between 2020 and 2025.
Exclusion criteria
Exclusion criteria: 1. Lack of consent. 2. Recurrent tumors upon inclusion. 3. The patients' primary treatment did not take place at the Freiburg University Hospital. 4. Primary tumor was not head and neck cancer. 5. Patients with second cancers. 6. Patients under 18 years of age. 7. Patients who cannot independently consent to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean values ??of the serum values ??of markers from the CXCL12/CXCR4 pathway in tumor patients (group of carcinoma patients vs. control group) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Mean values of markers from the CXCL12/CXCR4 pathway in tumor patients in saliva. - Mean values ??of the PCR results of markers from the CXCL12/CXCR4 pathway from remaining tumor tissue in tumor patients. - Mean values ??of the immunohistochemical results of markers from the CXCL12/CXCR4 pathway from remaining tumor tissue in tumor patients - Age of the patients at initial diagnosis - Locoregional metastases/distant metastases - HPV status - Gender - Graduation - R status - cTNM and pTNM status, UICC stage - Lymphatic vessel invasion, vascular invasion, pernineural sheath infiltration | — |
Countries
Germany
Contacts
Public ContactAndreas Knopf
Klinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Freiburg
Outcome results
None listed