Vegan diet in hereditary tumour syndromes

Vegan diet in hereditary tumour syndromes - VEGTUS-1

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035540

Enrollment

Registered

2024-12-13

Start date

2025-03-03

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lynch syndrome (ORPHA:144 )

Interventions

Group 1: 2-week vegan diet (before planned routine surveillance endoscopy) Group 2: 2-week ketogenic diet (before planned routine surveillance endoscopy) Group 3: Control (regular diet, no change in d

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Genetically confirmed Lynch syndrome - Age = 18 years - Ability to swallow plant-based foods - Body mass index (BMI) = 20 kg/m2 - Haemoglobin > 9 g/dl - Normal leucocytes - Creatinine 65 mg/dl - Total bilirubin < 2 mg/dl or < ULN - Written informed consent - Willingness and ability to perform blood, stool and urine tests Ability to remain in daily contact (by phone or email) with study personnel to communicate important clinical information, including daily body weight, blood pressure, health status and adverse events during the diet

Exclusion criteria

Exclusion criteria: - Unintentional weight loss = 5% in the last 3-6 months - Known HIV infection - Existing or planned pregnancy (positive pregnancy test in women, e.g. ß-HCG test in urine/serum) or breastfeeding - Diagnosis of type I or type II diabetes mellitus requiring medical treatment - Fasting glucose > 200 mg/dl - Impaired renal function (creatinine > 1.5mg/dl; GFR 2 mg/dl or AST/ALT 2-fold ULN - Post complete colectomy

Design outcomes

Primary

Measure	Time frame
Analysis of the intestinal immune infiltrate and circulating immune cells at the time of the routine monitoring endoscopy after the respective diet phase o scRNA sequencing of PBMCs and intestinal immune cells o Multicolour flow cytometry of PBMCs and intestinal immune cells o IF and IHC of intestinal biopsy samples	—

Secondary

Measure	Time frame
- Metabolic effects of the vegan diet - Changes in the intestinal microbiome - Influence on gastrointestinal adenoma load - Influence on body weight - Influence on blood count, liver values, retention parameters at the time of the routine monitoring endoscopy after the respective diet phase	—

Countries

Germany

Contacts

Public ContactJacob Nattermann

Universitätsklinikum Bonn Medizinische Klinik und Poliklinik I

jacob.nattermann@ukbonn.de+49 228 287-15260

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026