Impact of preoperative proton pump inhibitor (PPI) therapy on anastomotic leak rate after esophagectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00035536

Enrollment

229

Registered

2024-12-03

Start date

2024-11-05

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C15.9

Interventions

Group 1: Preoperative PPI-Therapy

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Patients with localized esophageal cancer who were treated neoadjuvantly depending on the tumor stage and who subsequently underwent esophageal resection • Replacement of the removed esophagus with a gastric conduit • Retrospective data analysis of all patients in the observation period from January 2016 to October 2024

Exclusion criteria

Exclusion criteria: • Advanced tumor stage with distant metastases and inoperability • Age < 18 years • Reconstruction method other than gastric conduit • Surgery due to esophageal perforation

Design outcomes

Primary

Measure	Time frame
Rate of postoperative, anastomotic leak	—

Secondary

Measure	Time frame
Postoperative Complications, measured with the Comprehensive Complication index	—

Countries

Germany

Contacts

Public ContactLukas Pollmann

Allgemein- und Viszeralchirurgie des Klinikums Dortmund

Lukas.Pollmann@klinikumdo.de+49 231 953 - 2143

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 5, 2026