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Evaluating the significance of histopathological studies of the ligamenta flava / posterior longitudinal ligament in patients with lumbar, thoracic and cervical spinal stenosis for early detection and screening of systemic amyloidosis

Evaluating the significance of histopathological studies of the ligamenta flava / posterior longitudinal ligament in patients with lumbar, thoracic and cervical spinal stenosis for early detection and screening of systemic amyloidosis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00035530
Enrollment
250
Registered
2025-02-18
Start date
2024-11-08
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M48.0

Interventions

Group 1: All patients with a degenerative cervical, thoracic or lumbar spinal stenosis that are operatively treated at the University Hospital Cologne within one year are candidates to be included in

Sponsors

Uniklinik Köln
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Operation at University Hospital Cologne Diagnosis of cervical, thoracic or lumbar spinal stenosis

Exclusion criteria

Exclusion criteria: Stenosis due to other reasons (tumor, infection)

Design outcomes

Primary

MeasureTime frame
Demonstration of amyloid deposits in the ligament flava / posterior longitudinal ligament in patients with degenerative spinal stenosis—

Secondary

MeasureTime frame
Demonstration of systemic amyloidosis in patients with a positive screening (identification of amyloid in intraoperative samples)—

Countries

Germany

Contacts

Public ContactMaximilian Christian Wankner

Uniklinik Köln

maximilian.wankner@uk-koeln.de+49 15152255762

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026