The influence of a four-week high-intensity interval endurance training on the microvascular function and structure in young cancer patients undergoing systemic treatment.

The influence of a four-week high-intensity interval endurance training on the microvascular function and structure in young cancer patients undergoing systemic treatment. - STIMULATE

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035528

Enrollment

Registered

2024-12-11

Start date

2024-12-17

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Solid tumor diseases (ICD-10 C.)

Interventions

Group 1: Cancer patients younger than 40 years, undergoing systemic therapy (chemotherapy and immunotherapy), without comorbidities, undergo a four-week high-intensity interval training (HIIT) program

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: - Tumor must be detectable by ultrasound imaging or CT scan - Curative medical treatment approach or life expectancy at least 6 months; - Good German language skills; - Signed written consent; - Healthy eye physiology (normal macula-OCT, optic-nerve head, fundus foto, visual acuity, inner ocular pressure)

Exclusion criteria

Exclusion criteria: - Obesity, hypertension, diabetes, glaucoma; - Previous history of cerebrovascular events; - Smoking; - Neurological disorders (e.g. epilepsy); - Chronic eye disease; - Metastatic cancer; - Previous history of immune therapy; - Shortened life expectancy of < 6 months; - Any diseases that do not allow sports activity in particular: Respiratory partial or global insufficiency; Permanent thrombocytopenia <10,000/µl, e.g., refractory autoimmune thrombocytopenia Congenital or acquired thrombocytopathies or coagulation disorders. Symptomatic CHD (clearance certificate required, stress ECG and cardiac ultrasound recommended if necessary) Severe anemia (requiring transfusion); - Participation in another exercise study;

Design outcomes

Primary

Measure	Time frame
Microvascular function (static and dynamic using Optical Coherence Tomography Angiography [OCTA] and Dynamic Retinal Vessel Analysis [DVA]) following 4 weeks of HIIT Time points: T0: Before 4 weeks of HIIT T1: After 4 weeks of HIIT	—

Secondary

Measure	Time frame
- Cardio-respiratory capacity, VO2max, after 4 weeks of HIIT - Health-related quality of life, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30, after 4 weeks of HIIT - Physical activity, Bewegungs- und Sportaktivität Fragebogen (BSA), after 4 weeks of HIIT - Depression and anxiety, Hospital Anxiety and Depression Score, after 4 weeks of HIIT	—

Countries

Germany

Contacts

Public ContactMichael Mendes Wefelnberg

Uniklinik Köln

michael.mendes-wefelnberg@uk-koeln.de+4922147842642

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026