Influence of perioperative factors on end-expiratory lung volume in patients with obesity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035513

Enrollment

Registered

2024-11-14

Start date

2024-11-18

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

E66.0

Interventions

Group 1: This study aims to investigate the influence of perioperative factors, including neuromuscular blockade, mechanical ventilation and pneumoperitoneum, on end-expiratory lung volume in patients

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Planned bariatric procedure at Mannheim University Hospital • Presence of grade 3 obesity (body mass index = 40kg/m2) • Consent to participate in the study

Exclusion criteria

Exclusion criteria: • Age < 18 years • Chronic lung diseases

Design outcomes

Primary

Measure	Time frame
- Delta end-expiratory lung impedance preoperative - postoperative - after application of positive airway pressure	—

Secondary

Measure	Time frame
• end-expiratory lung impedance preoperatively, postoperatively and after application of positive airway pressure • Global end-expiratory impedance of the lung (delta baseline postoperative/60min postoperative) • Pulmonary ventilation distribution • Regional lung compliance • Regional ventilation delay • Regional variation of the tidal volume • Physiological parameters of lung mechanics • SpO2/FiO2 ratio • Oxygen requirement one hour after extubation • Duration of oxygen therapy for a target SpO2>95% • Hypoxia (SpO2 < 90%) one hour after extubation • Duration of postoperative recovery room • Cumulative oxygen requirement recovery room • Anthropometric data (age, height, weight, ideal body weight)	—

Measure

Time frame

• end-expiratory lung impedance preoperatively, postoperatively and after application of positive airway pressure • Global end-expiratory impedance of the lung (delta baseline postoperative/60min postoperative) • Pulmonary ventilation distribution • Regional lung compliance • Regional ventilation delay • Regional variation of the tidal volume • Physiological parameters of lung mechanics • SpO2/FiO2 ratio • Oxygen requirement one hour after extubation • Duration of oxygen therapy for a target SpO2>95% • Hypoxia (SpO2 < 90%) one hour after extubation • Duration of postoperative recovery room • Cumulative oxygen requirement recovery room • Anthropometric data (age, height, weight, ideal body weight)

—

Countries

Germany

Contacts

Public ContactJörg Krebs

Universitätsmedizin Mannheim

Joerg.Krebs@umm.de+49 0621 383 3233

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026