Longitudinal monitoring of regional ventilation distribution and ventilator-associated lung injury in pediatric ARDS (MoVe LupARDS study)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035447

Enrollment

120

Registered

2024-12-23

Start date

2025-10-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

J80 P22 J80.06

Interventions

Group 1: n=60 patients with nARDS and pARDS patients ( intervention-group). 1) Work package 1: individualized EIT-based PEEP strategy and reduction of mortality and morbidity through daily assessment

rate of weaning failure/extubation failure

duration of ECMO therapy, in-hospital mortality) 2) Work package 2: Biomarker and proteomics analysis a. By means of biomarker profiling and proteomics analysis, significantly altered marker protei

ECMO therapy vs. no ECMO therapy

ECMO survival vs. death on ECMO

survival vs. death). 3) Work package 3: Diagnostics of regional ventilation distribution before and after interventions a. After physiotherapeutic respiratory therapy, significant changes/improvemen

Eligibility

Sex/Gender

All

Age

No minimum to 18 Years

Inclusion criteria

Inclusion criteria: - Infants/children with mild to severe respiratory failure (nARDS/ pARDS: exogenous, endogenous, infection-associated) and need for intubation with mechanical ventilation according to Montreaux and PALICC-2 guidelines (Emeriaud et al. 2023b; Luca et al. 2017) - Consent of the parents to participate in the study

Exclusion criteria

Exclusion criteria: - Patients with palliative care - Lack of parental consent - Contraindication against performing an EIT measurement in accordance with the approval (e.g. pacemaker)

Design outcomes

Primary

Measure	Time frame
An individualized EIT-based PEEP strategy leads to a significant reduction in ventilator-free days (VFD) on day 28 in patients with nARDS/pARDS.	—

Secondary

Measure	Time frame
In patients with nARDS/ pARDS, an individualized EIT-based PEEP strategy can lead to a reduction in: a) PEEP-adjustment and dynamic compliance, b) duration of mechanical ventilation or ventilator-free days on day 14, c) rate of weaning failure/ extubation failure, d) duration of ECMO therapy, e) in-house mortality	—

Countries

Germany

Contacts

Public ContactLukas Schröder

Uniklinik Bonn

lukas.schroeder@ukbonn.de+4922828737834

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Mar 14, 2026