Association of local oral infections with neuropathology: A cross-sectional study

Association of local oral infections with neuropathology: A cross-sectional study - Oral Infections and neuroinflammation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00035437

Enrollment

100

Registered

2024-11-08

Start date

2025-05-02

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Pathology

Interventions

Group 1: Patients who have undergone brain MRI in the last 3 years are invited for an intraoral examination. During the clinical assessment, health parameters of the periodontal/peri-implant tissues (

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patient age > 18 years 2. Fully edentulous patients 3. Partially edentulous patients with or without dental implants 4. Completely edentulous patients with or without dental implants

Exclusion criteria

Exclusion criteria: 1. Pregnant and breastfeeding women 2. Treatment with systemic antibiotics within the last 3 months

Design outcomes

Primary

Measure	Time frame
Association between oral health status assessed by the clinical parameters (bleeding on probing, probing depth values, number of missing teeth, suppuration) and neuroinflamamtion in the matter of the cerebrum assessed in the MRI images.	—

Secondary

Measure	Time frame
Association between pro- and anti-inflammatory biomolecule serum levels in blood and gingival fluid, and neuroinflammation in the matter of the cerebrum assessed in the MRI images.	—

Countries

Germany

Contacts

Public ContactAusra Ramanauskaite

J.W. Goethe Universität Frankfurt am Main

ausra.ramanauskaite@gmail.com+4917624205266

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026