No disease/health condition is being investigated. Study of the effects of MCTs and carbohydrates on the metabolism of healthy subjects.
Conditions
Interventions
Group 1: The emulsified intervention drink is composed of water, flavouring, sweetener, medium-chain triglycerides (MCT) (0.2 g/kg body weight), and glucose (0.2 g/kg body weight).
Group 2: The emulsi
Sponsors
FH Münster
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Normal weight (BMI = 18.5 – 25.0)
Exclusion criteria
Exclusion criteria: - Pregnancy, breastfeeding - Presence of a serious/chronic illness (e.g. cancer, circulatory diseases, thyroid defects, intestinal diseases) or acute illness at the time of the examination - Known metabolic disease (e.g. lipid metabolism disorder, diabetes mellitus type 1 or 2) - Taking medication (exception: contraceptives) - Taking food supplements that affect lipid metabolism (e.g. MCT) - Mental or speech impairments - Low-carb or other forms of nutrition with a permanent reduction in carbohydrate intake (DGE requirement: at least 50% carbohydrates) - Diagnosed eating disorders - Whole blood donation within the last 3 months and blood plasma donation within the last 4 weeks before the start of the study - Intolerance to sweeteners (e.g. cyclamate, thaumatin, aspartame)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ß-hydroxybutyrate (ßHB) in venous blood, measured before the intervention (t0) and 30, 60, 120, 180, 240 and 300 minutes (t2 - t6) after the intervention. Blood is taken via an indwelling venous catheter. | — |
Secondary
| Measure | Time frame |
|---|---|
| - body weight via body scales before the intervention days - height via stadiometer before the intervention days - body mass index (BMI) via calculation from body weight and height before the intervention days - body composition via bioelectrical impedance analysis (BIA) before the intervention days - insulin, glucose and essential/non-essential fatty acids in venous blood, measured before the intervention (t0) and 30, 60, 120, 180, 240 and 300 minutes (t1 - t6) after the intervention - Glucose and ßHB in capillary blood, measurement before the intervention (t0) and 60, 120, 180, 240 and 300 minutes (t2 - t6) after the intervention. - Acetone in the breath using a mobile breath acetone measuring device before the intervention (t0) and 30, 60, 120, 180, 240 and 300 minutes (t2 - t6) after the intervention - Ketone bodies, leukocytes, nitrite, pH, protein, glucose, urobilinogen, bilirubin, blood in the urine by collecting spontaneous urine and analysing it with urine strips between t0 and t6 - Resting energy expenditure (REE) and macronutrient contributions to energy metabolism via indirect calorimetry before the intervention days and once per intervention day | — |
Countries
Germany
Contacts
Public ContactTobias Fischer
FH Münster
Outcome results
None listed