Evaluation of trigeminovascular sensitisation in migraine patients by transcutaneous C-fiber stimulation.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00035363

Enrollment

Registered

2024-11-13

Start date

2026-03-31

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G43

Interventions

Group 1: Case group: Patients with migraine diagnosed according to ICHD-3 criteria. Questionnaires, neurobiological characterisation, C-fiber stimulation with recording of EEG data. Group 2: Control

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - Patients with migraine diagnosed according to ICHD-3 criteria - Subjects without migraine or headache disorders for the control group

Exclusion criteria

Exclusion criteria: - Other serious illness that could influence the study results - Use of psychostimulants or other medications that could influence the study results - Inability to understand the study instructions - Epilepsy - Pacemaker - Current pregnancy

Design outcomes

Primary

Measure	Time frame
The amplitude of the evoked potentials is used as the primary endpoint. The aim is to obtain a measure of the sensitization of migraine patients through the evoked potentials.	—

Secondary

Measure	Time frame
As a secondary endpoint, habituation to the pain stimulus will be investigated. Finally, the physiological parameters will be correlated with the CGRP levels and questionnaire.	—

Countries

Germany

Contacts

Public ContactClaudia Sommer

Universitätsklinikum Würzburg Neurologische Klinik

claudia.sommer@uni-wuerzburg.de+49 931 201-23763

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026