Effects of exercise training on the neuronal regulation of food intake

Effects of exercise training on the neuronal regulation of food intake - Ex and Eat

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035328

Enrollment

Registered

2024-12-12

Start date

2025-04-08

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

overweight obesity class I, ICD10, E66.00 insulin resistence, prediabetes (HbA1c: 5,7-6,4%) E66 R73.0

Interventions

Group 1: Randomised, controlled, balanced, cross-over study design Study vistit 1: (1a) MRI/MRS measurements of the brain I - fMRI: brain activity, functional connectivity, food-cue-reactivity - 31P

Eligibility

Sex/Gender

Male

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: - men - HbA1c value <5.7% or HbA1c value between 5.7% and = 6.4% - BMI between 25.0 - 34.9 kg/m2 - Ability to give informed consent to participate in the study - Written and verbal consent to participate in the study

Exclusion criteria

Exclusion criteria: - Serious internal diseases - Cardiovascular, neurological or psychiatric diseases - Cancer - Alcohol, drug or medication dependency or abuse - Night work - Contraindications to (f)MRI/S measurements

Design outcomes

Primary

Measure	Time frame
Physical training alters the neuronal response to visual food stimuli and this effect differs between subjects with and without insulin resistance.	—

Secondary

Measure	Time frame
(1) Physical training alters cerebral energy metabolism and this effect differs between subjects with and without insulin resistance. (2) Correlations exist between training-induced changes in neuronal responses to visual food stimuli and cerebral energy metabolism with (a) subjective feelings such as hunger, satiety, appetite, (b) hormones regulating food intake (such as ghrelin, PYY) and (c) the expression of miRNAs related to metabolically relevant genes. (3) In the neuronal response to visual food stimuli with a high hedonic value, a differentiation can be made between compensators and non-compensators, whereby the effect of physical training on the change in the neuronal response to visual food stimuli with a high hedonic value is less pronounced in compensators than in non-compensators. (4) The hedonic valence of food is primarily determined by liver fat content and peripheral insulin sensitivity (e.g. HOMA-IR) and not by body fat mass.	—

Measure

Time frame

(1) Physical training alters cerebral energy metabolism and this effect differs between subjects with and without insulin resistance. (2) Correlations exist between training-induced changes in neuronal responses to visual food stimuli and cerebral energy metabolism with (a) subjective feelings such as hunger, satiety, appetite, (b) hormones regulating food intake (such as ghrelin, PYY) and (c) the expression of miRNAs related to metabolically relevant genes. (3) In the neuronal response to visual food stimuli with a high hedonic value, a differentiation can be made between compensators and non-compensators, whereby the effect of physical training on the change in the neuronal response to visual food stimuli with a high hedonic value is less pronounced in compensators than in non-compensators. (4) The hedonic valence of food is primarily determined by liver fat content and peripheral insulin sensitivity (e.g. HOMA-IR) and not by body fat mass.

—

Countries

Germany

Contacts

Public ContactCarina Walowski

UKSH Lübeck, Medizinische Klinik I, Universität zu Lübeck, AG für Endokrinologie und Diabetes

carina.walowski@uni-luebeck.de+49 451 3101 7829

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Aug 9, 2026