Postoperative delir Postoperative cognitive deficits
Conditions
Interventions
Group 1: Coronary artery bypass grafting (CABG)
Group 2: Aortic valve replacement (AVR)
Sponsors
Kerckhoff-Klinik, Heart and Brain Research Group
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: -Coronary Artery Bypass Grafting (CABG) -Aortic Valve Replacement (AVR) -Sufficiently good knowledge of the German language, as the neuropsychological tests are language-dependent. -Capable of giving informed consent -Written consent from
Exclusion criteria
Exclusion criteria: -Preoperative psychiatric and neurological conditions (dementia, depression, stroke) with acute symptoms that could affect neuropsychological testing -Re-operation -Emergency surgery -Pacemaker -Acute medical treatment for a heart-related condition within the last 3 months (stent, TAVI, heart attack, myocarditis…)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Which preoperative HRV biomarkers are associated with the development of postoperative delirium (POD) in patients with CABG? | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Which preoperative HRV biomarkers are associated with the development of postoperative delirium (POD) in patients undergoing AVR? 2. Which preoperative HRV biomarkers are associated with the development of postoperative cognitive deficits (POCD) in patients undergoing CABG? 3. Which preoperative HRV biomarkers are associated with the development of POCD in patients undergoing AVR? 4. Which preoperative stress markers (salivary biomarkers and emotional stress measures) are associated with POD, POCD, and postoperative emotional burden in patients undergoing CABG and AVR? | — |
Countries
Germany
Contacts
Public ContactMarius Butz
Kerckhoff-Klinik, Heart and Brain Research Group
Outcome results
None listed