Utilizing Discarded Livers from Donors with a History of Cancer for Patients Lacking Access to Standard Allocation: A Compassionate Use Exploratory Study

Utilizing Discarded Livers from Donors with a History of Cancer for Patients Lacking Access to Standard Allocation: A Compassionate Use Exploratory Study - TRANSMIT

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035308

Enrollment

Registered

2024-10-21

Start date

2024-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal cancer liver metastases (CRC-LM) Intrahepatic cholangiocarcinoma (iCCC) Perihilar cholangiocarcinoma (phCCC) Hepatocellular carcinoma (HCC) C78.7 C22.1 C24.0 C22.0

Interventions

Group 1: Liver transplantation in patients with liver malignancies (CRC-LM, i/phCCC, HCC) who are not eligible for regular organ allocation using donor organs from individuals with a current or past h

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. Full eligibility and fitness to undergo liver transplantation. Full eligibility and fitness to receive effective neoadjuvant or adjuvant systemic therapy. Presence of non-resectable disease. Absence of extrahepatic disease. Approval from the interdisciplinary national tumor board. Approval from the interdisciplinary liver transplant board.

Exclusion criteria

Exclusion criteria: Disease progression under systemic therapy.

Design outcomes

Primary

Measure	Time frame
Utilization rate of donor organs that would otherwise be discarded	—

Secondary

Measure	Time frame
Overall survival Progression-free survival, with recurrence described separately as hepatic and extrahepatic. Safety endpoint: Tumor transmission rate at one and three years.	—

Countries

Germany

Contacts

Public ContactDominik Koch

Klinik für Allgemein-, Viszeral und Transplantationschirurgie der LMU München

dominik.koch@med.uni-muenchen.de+498944000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026