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Decoding Dynamic Reciprocal Neural Mechanisms underlying Reactive Agression: Insights from fMRI and fNIRS Hyperscanning

Decoding Dynamic Reciprocal Neural Mechanisms underlying Reactive Agression: Insights from fMRI and fNIRS Hyperscanning - Cody - DeCOding Dynamic Reciprocal Neural Mechanisms

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00035286
Enrollment
150
Registered
2025-03-06
Start date
2025-05-01
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This study is transdiagnostic and will include several psychiatric disorders of axis I and II according to ICD-10. Excluded are developmental disorders, mental retardation and neurodegenerative disorders.

Interventions

Group 1: Psychiatric in-/outpatients We will include 75 adolescents with psychiatric disorders (axis I or II), recruited from Project TRR Q01 (Excl. neurodegenerative or developmental disorders, ment

Sponsors

Sektion „Klinische Neuropsychologie des Kindes- und Jugendalters“ an der Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Uniklinik der RWTH Aachen
Lead Sponsor

Eligibility

Sex/Gender
All
Age
13 Years to 18 Years

Inclusion criteria

Inclusion criteria: • Clear understanding of the study information and personally and voluntarily signed consent form by the participants and their legal guardians. • Good understanding of the German language. • For patients: any mental disorder according to DSM-5/ ICD-10/ ICD-11.

Exclusion criteria

Exclusion criteria: • Severe mental retardation (IQ<50) • Inability to comply with the study protocol. • Participants with severe somatic or neurological disorders that affect the central nervous system. • MRI contraindications will be further exclusion criteria (e.g. active implants, metal in body). • For healthy controls: any mental disorder according to DSM-5/ ICD-10/ ICD-11 • Pregnancy • other chronic or acute physical diseases

Design outcomes

Primary

MeasureTime frame
- daily reactive aggression level measured via questionnaires/Ecological momentary assessment (EMA) gathered in project Q1 - Questionnaire data gathered in project Q1 (Affective Style Questionnaire (ASQ), Aggression Questionnaire (BPAQ), Selfishness Questionnaire (SQ), Barratt Impulsiveness Scale (BIS-15), Becks Depression Inventory II (BDI-II), Childhood Trauma Questionnaire (CTQ), Bermond-Vorst Alexithymia Questionnaire (BVAQ), Aggression-ES-A) - fNIRS-/fMRT-brain activity and interpersonal neural synchrony during several social situations in which mistrust, social exclusion and provocation are manipulated - Behavioral data will be recorded on video and coded for affective states and behavioral-emotional synchrony in dyadic / group setting

Secondary

MeasureTime frame
Peripheral physiological parameters recorded during the hyperscanning (heart rate, heart rate variability), affect and body movements

Countries

Germany

Contacts

Public ContactVanessa Reindl

Sektion „Klinische Neuropsychologie des Kindes- und Jugendalters“ an der Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Uniklinik der RWTH Aachen

vreindl@ukaachen.de+40 241 80-85504

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026