Influence of the rate of pressure rise under Time Controlled Adaptive Ventilation on other ventilation parameters

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035282

Enrollment

Registered

2024-10-15

Start date

2023-10-03

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with need of mechanical ventilation

Interventions

Group 1: 3 tests of 10 minutes each per patient (different settings for rate of pressure rise)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - invasive ventilation - ventilation using TCAV-protocol

Exclusion criteria

Exclusion criteria: - Failure to meet inclusion criteria - Contraindications for ventilation under the TCAV protocol: obstructive ventilatory disorder, undrained pneumothoraces - Refusal to participate in the study - Implanted pacemakers or defibrillators - Severe skin lesions or thoracic burns

Design outcomes

Primary

Measure	Time frame
Evaluation of the influence of the ramp setting on the above parameters associated with a VILI in invasively ventilated patients without spontaneous breathing efforts	—

Secondary

Measure	Time frame
Measurement of regional lung impedance over time using electrical impedance tomography (EIT) as a correlate for end-expiratory lung volume	—

Countries

Germany

Contacts

Public ContactPatrick Rehn

Universitätsklinik Heidelberg

patrick.rehn@med.uni-heidelberg.de+4962215639435

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026