Rheumatoid arthritis
Conditions
Interventions
Group 1: Patients with rheumatoid arthritis and osteoporosis measured using DXA (Dual Energy X-ray Absorptiometry)
Sponsors
Justus-Liebig-Universität Gießen, Campus Kerckhoff
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Written informed consent to participate in the study. 2. Understanding of the study procedures and willingness to adhere to all procedures throughout the study. 3. Diagnosis of RA that meets the 2010 EULAR/ACR classification criteria. 4. Recently conducted (max. 2 weeks prior) osteological baseline diagnostics, including bone mineral density measurement using DXA.
Exclusion criteria
Exclusion criteria: a. Diagnosis of another rheumatological disease other than RA b. Known osteoporosis c. Present or past osteoporotic fractures d. Current implementation of an osteospecific therapy (antiresorptive or anabolic) e. Intake of glucocorticoids > 5 mg prednisolone equivalent/day f. Calcium supplementation > 1000 mg/day g. Vitamin D supplementation > 5000 IU/day h. Severe vitamin D deficiency (cholecalciferol < 15 µg/l) i. Rickets j. Type I diabetes mellitus k. Intake of growth hormones, estrogens, aromatase inhibitors, other tumor therapy l. Intake of SSRIs m. Heart failure with a left ventricular ejection fraction < 35% n. Hyperthyroidism o. Plasmacytoma or monoclonal gammopathy of uncertain significance p. Anorexia nervosa (BMI < 18.5 kg/m²) q. Employee or direct relative of an employee of the study center or steering committee r. Previous participation in this clinical study s. Planned extended stay outside the region that prevents adherence to the study protocol t. Insurmountable language barrier u. Lack of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the calcium isotope ratio from blood (d44/42CaBlood) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Determination of the calcium isotope ratio from urine (d44/42CaUrin) • Determination of the calcium isotope ratio depending on sex, disease activity of RA, functional health, presence of autoantibodies of RA (RF & ACPA), and administered prednisolone therapy • Comparison of the calcium isotope ratio with parameters of bone metabolism | — |
Countries
Germany
Contacts
Public ContactPhilipp Klemm
Justus-Liebieg-Universität, Campus Kerckhoff
Outcome results
None listed