Age-related cognitive decline
Conditions
Interventions
Group 1: Adaptive VR-based cognitive training: Test subjects complete 10 sessions of adaptive VR training in which the intensity of the game is adaptively adjusted to the individual cognitive load.
Gr
Sponsors
VRalive®? GmbH
Eligibility
Sex/Gender
All
Age
60 Years to 85 Years
Inclusion criteria
Inclusion criteria: Subjects without a diagnosis of a neurocognitive disorder (MCI, dementia, AD) Signed declaration of consent and willingness to participate
Exclusion criteria
Exclusion criteria: MoCA value 160 mmHg) mental illnesses (e.g. schizophrenia, addiction, substance dependence) that do not allow the person concerned to assess the nature, scope and possible consequences of the scientific study Inability to understand the nature of the study and to give legally valid informed consent Indications that the subject is unlikely to attend the required appointments (e.g. unwillingness to cooperate, lack of compliance) Participation in other scientific studies within the last 12 weeks before the start of the study Autoimmune diseases in the acute stage Therapy with opiates, calcium antagonists or benzodiazepines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary aim of this scientific study is to investigate the effectiveness of the combination of adaptive VR-based cognitive training and classical electrical stimulation by comparing it with no intervention (controls). To this end, the performance of the working memory (N-back) immediately after the intervention (day 9) is to be compared with the values of the initial measurement (day -7), whereby an improvement is to be achieved (investigation of the short-term effect, primary endpoint). | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychological test results: Success of active electrical stimulation: improvement in N-back performance between initial measurement (day -7) and measurement after the intervention (day 9) compared to sham stimulation. Long-term effect: Improvement in N-back performance 3 months (day 100) after combined intervention of VR-based cognitive training with classical or (sham) electrical stimulation in relation to the initial measurement. Success of VR-based cognitive training: improvement in N-back performance between baseline measurement (day -7) and post-intervention measurement (day 9) compared to classical computer-based training. Success of the adaptivity of VR-based cognitive training: Improvement in N-back performance between initial measurement (day -7) and measurement after the intervention (day 9) compared to non-adaptive VR-based cognitive training. Improvement of the global cognitive state, measured using the MoCA (transfer effect): Analysis of group differences and changes over time after the last stimulation (day 9) and after 3 months compared to the screening appointment (day -20). Improvement in short-term memory, measured using the DST (transfer effect): Analysis of group differences and changes over time after the last stimulation (day 9) and after 3 months compared to the initial measurement (day -7). Improvement in word naming and word finding, measured using the BNT (transfer effect): Analysis of group differences and changes over time after the last stimulation (day 9) and after 3 months compared to the initial measurement (day -7). Improvement in non-verbal intelligence (logical thinking), measured using the AMRT (transfer effect): Analysis of group differences and changes over time after the last stimulation (day 9) and after 3 months compared to the initial measurement (day -7). Improvement in associative memory, measured using the FNAT (transfer effect): Analysis of group differences and changes over time after the last sti | — |
Countries
Germany
Contacts
Public ContactLukas Diedrich
Universitätsmedizin Göttingen
Outcome results
None listed