postoperative nausea and vomiting (PONV) postoperative opioid consumption and pain severity
Conditions
Interventions
Group 1: Prospective single center audit with the aim of investigating the pharmacogenetics of important anaesthesia-relevant drugs in patients with prostate carcinoma undergoing robot-assisted laparo
Sponsors
Marienhospital Herne, Universitätsklinikum der Ruhr-Universität Bochum
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Planned RALPE for prostate carcinoma Written declaration of consent Age = 18 years Anaesthesia according to hospital standard ASA II-III
Exclusion criteria
Exclusion criteria: Refusal of participation by the patient Language barrier Age < 18 years Clinically relevant aortic stenosis Contraindications to one of the anaesthesia procedures; e.g. disposition to malignant hyperthermia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. incidence of postoperative nausea and vomiting as a function of SNPs: CHRM3 rs2165870, DRD2 rs1800497, 5-HTTLPR rs4795541, HTR3B rs3782025, KCNB2 rs349358 2. postoperative opioid consumption and pain severity (NRS) as a function of the SNPs: COMT rs4680, OPRM1 rs1799971 3. duration until complete relaxation during induction of anaesthesia and total dose of intraoperative rocuronium administration depending on the genotype of the SNPs: SLCO1A2 rs7967354, SLCO1A2 rs11045995, NR1I2 rs2472677, SLCO1A2 rs4762699, ABCB1 rs12720464, rs1055302, rs1128503, OATP1B1 SLCO1B1 rs2306283, OATP1B1 SLCO1B1 rs2306283 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. quality of recovery (QoR-15) = patient well-being after surgery (RALPE) 2. Postoperative complications based on the Comprehensive Complication Index (CCI) | — |
Countries
Germany
Contacts
Public ContactUlrich Frey
Marienhospital Herne, Universitätsklinikum der Ruhr-Universität Bochum
Outcome results
None listed