G35
Conditions
Interventions
Group 1: Patients with multiple sclerosis
the following tests are completed/the following questionnaires are completed:
BDI
FEAG
FEDA
MoCA
WMSI-IV
RAVLT
ESS
EMQS
FIS-D
PSQI
SDMT
In addition, specifi
Sponsors
Carl von Ossietzky Universität Oldenburg - Abteilung für Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of multiple sclerosis according to the revised McDonald criteria (Thompson et al., 2018), all subgroups (relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) and primary progressive multiple sclerosis (PPMS)) and all degrees of severity are permitted. Patients must be capable of providing information and be able to reflect sufficiently on the decision to participate in the study; this criterion is checked before the information is provided. The prerequisite for participation in the study is German as a native language.
Exclusion criteria
Exclusion criteria: Exclusion criteria for MS patients: Signs of depression (BDI > 20) Taking medication that modifies memory performance (e.g. anticholinergics for the treatment of bladder weakness) Diseases other than multiple sclerosis that can impair brain function Exclusion criteria for the control subjects: Presence of a psychiatric or neurological illness Regular use of medication that interacts with the function of the CNS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| H1: Patients with multiple sclerosis show reduced memory performance in retaining verbal information (1. RAVLT recall after 7 days / RAVLT recall after 30 min, 2. WMSI recall after 7 days / WMSI recall after 30 min) (indicated as: QRAVLT or QWMS) after 7 days compared to age-, gender- and education-matched healthy subjects. | — |
Secondary
| Measure | Time frame |
|---|---|
| N1: Disturbances in the recall of verbal information over a longer period of time are an expression of a subjectively experienced memory impairment and correlate with the questionnaires collected, with a negative correlation of QRAVLT and QWMS to FEAG and EMQ and a positive correlation to FEDA. N2: Disturbances in the retrieval of verbal information over a longer period of time are due to impaired sleep-bound memory consolidation and therefore correlate with the sleep score. N3: Disturbances in the recall of verbal information after a longer period of time correlate with the severity of fatigue and therefore also with the FIS-D score. | — |
Countries
Germany
Contacts
Public ContactKarsten Witt
Carl von Ossietzky Universität Oldenburg - Abteilung für Neurologie
Outcome results
None listed