C79.3
Conditions
Interventions
Group 1: LITT for rbreast cancer metastases:
As study-specific measures, prospective collection of scores and questionnaires will occur:
Functional Status:
- modified Rankin Score (mRS)
- Karnofsky P
Sponsors
Neurochirurgische Klinik, Sektion stereotaktische Neurochirurgie
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: -Patients of legal age with previously histologically confirmed breast cancer and imaging suspicious of 1-4 symptomatic brain metastases -Indication for LITT treatment with biopsy sampling if open resection is considered too riskyresection is deemed too risky or not possible by specialist neurosurgeon. Common factors in favor of LITT treatment: - tumor volume <30cm3 and/or <2.5cm diameter along the shortes axis of extension - Karnofsky Performance Index of 70% or higher) - supratentorial location of the targeted metastasis
Exclusion criteria
Exclusion criteria: - Patients not able to give consent - MRI imaging not possible - Expected survival <3 months - Presence of absolute contraindications for general anesthesia and/or surgery - Pregnant patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurological and functional status as well as quality of life of patients with patients with breast cancer brain metastases and LITT therapy (collected via scores: mRS, KPS, NIHSS and validated questionnaires: HADS-D, EORT QLQ-BN20, EORT QLQ-C30). | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression-free survival & overall survival (Kaplan-Meier curves). Rate, type and severity of complications of LITT Comparison between planned and actual ablation volume Comparison between planned and actual location of the laser catheter tip Course of preoperative expected and postoperative experienced treatment burden (NRS-based). | — |
Countries
Germany
Contacts
Public ContactMartin Jakobs
Neurochirurgische Klinik, Sektiomn stereotaktische Neurochirurgie
Outcome results
None listed