Confocal laser endomicroscopy in neurosurgery for the local detection of brain tumour tissue and tissue boundaries

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00035177

Enrollment

100

Registered

2024-09-27

Start date

2022-12-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C70.0 C71 C79 D37-D48 D10-D36 C81-C96

Interventions

Group 1: The objective of this study is to assess the precision of fluorescence-assisted confocal laser endomicroscopy (CLE, CONVIVO® System, Carl Zeiss, Meditec, Oberkochen, Germany) in intraoperativ

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Consenting patients >18 years of age with an indication for resection of a CNS/PNS tumour.

Exclusion criteria

Exclusion criteria: Known allergies/hypersensitivities to fluorescein sodium, patients with impaired kidney function/dialysis, breastfeeding, pregnancy

Design outcomes

Primary

Measure	Time frame
Sensitivity und Specificity of CLE. In order to achieve this, the result of the neuropathologist's findings (tumour presence/absence, tumour type) is compared with the frozen section diagnosis and the final neuropathological diagnosis.	—

Secondary

Measure	Time frame
Evaluation of the possibility of displaying CLE images in different tumour entities of the peripheral and central nervous system	—

Countries

Germany

Contacts

Public ContactMatteo Mario Bonsanto

UKSH Campus Lübeck, Klinik für Neurochirurgie

MATTEO.BONSANTO@UKSH.DE+4945150043211

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: May 1, 2026