Influence of peripheral inflammation on the blood-brain barrier assessed via quantitative MRI

Influence of peripheral inflammation on the blood-brain barrier assessed via quantitative MRI - SPACE

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00035108

Enrollment

110

Registered

2025-09-15

Start date

2025-04-01

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

We will only examine healthy controls.

Interventions

Group 1: Participants in the healthy control group will complete three study visits: Visit 1: Informed consent, blood collection, administration of questionnaires assessing mental health and quality o

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: • healthy participants, who have a planned Covid-19 vaccination or healthy participants without a planned Covid-19 vaccination • Age between 18 and 65 years

Exclusion criteria

Exclusion criteria: • Current mental disorders requiring treatment • Severe somatic diseases (such as pneumonia, sepsis, stroke, liver/kidney transplant, thyroid disorders are included only if TSH is normal) • Current pregnancy or breastfeeding • MRI exclusion criteria: tattoos in the neck/head area, permanent make-up, magnetically attached dentures, metallic/magnetic implants (pacemaker, defibrillator, joint endoprosthesis, heart valve, stent, metal, silicone, vascular/surgical clips, vascular endoprosthesis, metal pins, skin chips, garnet/other metal splinters, insulin pump, painkiller pump, neurostimulator, hearing implant) • Exclusion criteria for contrast agent (CA) administration: elevated creatinin level, liver transplant, kidney transplant, gadovist allergies • Fever, severe infection symptoms, urinary tract infection within the last 7 days before T1 • Antibiotic treatment within the last 14 days before T1

Design outcomes

Primary

Measure	Time frame
Change in blood-brain-barrier permeability after inflammation measured via quantitative MR imaging	—

Secondary

Measure	Time frame
Association of change in inflammatory markers with change in blood-brain-barrier permeability after inflammation	—

Countries

Germany

Contacts

Public ContactMareike Aichholzer

Klinik für Psychiatrie, Psychosomatik und Psychotherapie, Universitätsklinikum Frankfurt

aichholzer@med.uni-frankfurt.de069 6301 5222

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026