Skip to content

Investigation of intrusive emotional internal images with reference to neurobiological bases of emotion processing - a translational study in patients with social anxiety disorder

Investigation of intrusive emotional internal images with reference to neurobiological bases of emotion processing - a translational study in patients with social anxiety disorder - ISI

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
DRKS
Registry ID
DRKS00035107
Enrollment
120
Registered
2024-09-23
Start date
2024-10-01
Completion date
Unknown
Last updated
2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F40.1

Interventions

Group 1: Participants who meet the diagnostic criteria for social anxiety disorder, can report at least one intrusive social image and will be given a visual-spatial interference task (bringing the in

Sponsors

Institut für Translationale Psychiatrie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Report of at least one intrusive emotional images with social reference. HC: individuals without any psychiatric disorder current or lifetime

Exclusion criteria

Exclusion criteria: Exclusion criteria: For healthy control, any current or life-time psychiatric disorder is an exclusion criterion. Further exclusion criteria for all subjects: Centrally acting medication, neurological abnormalities, organically induced mental illness, dementia, CNS injuries, MRI contraindications, left-handedness.

Design outcomes

Primary

MeasureTime frame
The primary endpoint is a reduction in intrusive social images, in comparison between the intervention and control conditions. As this is a feasibility study, the aim is only to investigate whether a reduction is possible with the help of the intervention; a quantitative criterion for the success of the reduction is not yet defined.

Secondary

MeasureTime frame
As secondary endpoints, activation patterns in fMRI (imagery provocation task and modulation task) will be investigated. We expect an overlap of neuronal activity during imagination of an intrusive social image and playing Tetris in MRI. In addition, we expect an increased activation of brain areas involved in emotion processing during the imagination of an intrusive social image compared to a neutral image. We also expect a correlation between neuronal activity during imagination of an intrusive social image and emotion-regulation capabilities measured via questionnaires.

Countries

Germany

Contacts

Public ContactElisabeth Leehr

Institut für Translationale Psychiatrie

leehr@uni-muenster.de+49251 8351860

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026