G40
Conditions
Interventions
Group 1: Stereotactic fractionated radiation with photons (linac-based) of the epileptogenic zone (defined by MRI imaging, together with epileptologist and neurosurgeon), over 2 weeks
Sponsors
Klinik für Strahlentherapie und Radioonkologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Epilepsy diagnosis (of the structural non-neoplastic type) made by an epileptologist and considered pharmacoresistant and inoperable (e.g. due to localization in an eloquent zone or an unacceptable perioperative risk due to underlying or concomitant diseases) or surgery is refused by the patient; - Imaging evidence by means of cMRI of an anatomical region that correlates with the epilepsy diagnosis and can be clearly defined (this is done by means of an interdisciplinary conference where radiotherapists, neuroradiologists, neurosurgeons and epileptologists are present); - multidisciplinary review of the indication for radiotherapy by radiotherapy and epileptology, with the patient being classified as a suitable candidate for stereotactic radiosurgery; - written informed consent.
Exclusion criteria
Exclusion criteria: - pregnancy; - history of radiotherapy in the central nervous system; - patients with cancer predisposition syndromes (e.g. Li-Fraumeni) where each radiation treatment must be indicated with extreme caution.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in seizure frequency (measured using the radiotherapy-adapted Engel classification or RAEC from I or seizure free to IV no significant changes) 6 months after completion of radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| - Side effects of radiotherapy (in particular radionecrosis) - Longitudinal changes in quality of life | — |
Countries
Germany
Contacts
Public ContactDavide Scafa
Klinik für Strahlentherapie
Outcome results
None listed