I50
Conditions
Interventions
Group 1: Men with high-grade aortic valve stenosis or high-grade mitral valve insufficiency above the age of 40 years
The aim is to investigate the relationship between the myocardial gender-specific
Sponsors
Universitätsmedizin Göttingen
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Sufficient language skills to fully understand the information and the information sheet in german - Patients who have an indication for open heart aortic and/or mitral valve surgery using the heart-lung machine, independent of this study
Exclusion criteria
Exclusion criteria: - Age 80 years - Insufficient language skills to understand the information and the information sheet - Cognitive limitations that make it difficult to understand the information and the information sheet - Patient care situation or neurological conditions that impair the patient's ability to give consent - Renal insufficiency requiring dialysis - Acute endocarditis - Known coronary heart disease - Post myocardial biopsy or already planned myocardial biopsies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A typical primary endpoint is not part of the study. Target of this studie is to examine the transcriptome of patients onto gender-specific features and if there is than we want to search for different influences onto the valvular heart failure of our patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of myocardial and haematopoietic transcriptome; correlation of gender specific transcriptome with clinical factors (e.g. ejection fraction; diastolic/ systolic function) | — |
Countries
Germany
Contacts
Public ContactHassina Baraki
Universitätsmedizin Göttingen
Outcome results
None listed