E66.0
Conditions
Interventions
Group 1: 15 Patients with obesity with planned Roux-en-Y gastric bypass
fMRI with investigation of central nervous insulin sensitivity prior to surgery
fMRI with investigation of central nervous insul
Sponsors
Chirurgische Klinik der Universitätsmedizin Mannheim
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: - Obesity with BMI >35kg/m^2 - Planned metabolic-bariatric surgery via Roux-en-Y Gastric Bypass - Insulin Resistance or absence of impaired glucose matabolism - Cognitive ability to grasp the consequences and extent of the trial - Ability for written informed consent - Ability to understand the German language to an extent that the consequences and extent of the trial can be understood fully
Exclusion criteria
Exclusion criteria: - Weight >120kg - Non-MRI compatible metallic implants - Stents or tattoos - Dental implants or non-removable piercings - Extensive claustrophobia - Non-removable hormonal patches or medical pumps - Inability to understand the consequences and extent of the study - Expected incompliance - Pregnancy - Medically treated Diabetes Mellitus Type II - Diabetes Mellitus Type I - Diabetes Mellitus Type III
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evolution of central nervous insulin sensitivity following intranasal insulin over the course of Roux-en-Y gastric bypass as metabolic-bariatric surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Hunger and Hungermanagement upon stimulus Laboratory Values regadring glucose metabolism, liver, coagulation, nutritional status Body composition via bioimpedance analysis Dietary behavior Urine status | — |
Countries
Germany
Contacts
Public ContactMirko Otto
Chirurgische Klinik der Universitätsmedizin Mannheim
Outcome results
None listed