S93.2 M23.61
Conditions
Interventions
Group 1: Longitudinal observation with simultaneous measurement of the hormone profile and biomechanics during functional assessments at 4 points in the menstrual cycle and during 2 menstrual cycles.
Sponsors
ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Eligibility
Sex/Gender
Female
Age
18 Years to 34 Years
Inclusion criteria
Inclusion criteria: - Recreational athletes with 3-10 hours of exercise per week - Eumenorrheic: self-reported cycle length between 24 and 35 days resulting in at least 9 periods per year or users of non-hormonal (copper) intrauterine contraceptive devices - No injuries requiring medical attention or rehabilitation during the last 6 months - Able to perform jumping, hopping, and cutting movements - Body mass index < 28 kg/m2 - Willingness to apply the TAP®-Device for minimally invasive blood analysis - Ability to give informed consent
Exclusion criteria
Exclusion criteria: - Complete rupture of ligaments in the lower extremities - Surgical reconstruction of ligaments in the lower extremities - Pregnancy or breast feeding - Acute or chronic diseases (neurological, cardiopulmonary, musculoskeletal, untreated endocrinologic disorders) - Use of systemic effective hormonal contraceptives such as combined contraceptives (pill, vaginal ring, transdermal patch), progestin-only preparations, or long-acting reversible contraceptives (implants, injections) or non-systemic intrauterine hormonal devices (IUD) - Any kind of hormone replacement therapy (transdermal or peroral) in the past 3 months - Any kind of anti-hormonal therapy (e.g. letrozole, tamoxifen)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomechanical variables related to acute ligamentous lower extremity injuries: - peak hip flexion angles - peak knee flexion, abduction, internal rotation angles - peak knee flexion and abduction moments - peak ankle plantarflexion, dorsiflexion, inversion angles - ankle dorsiflexion/plantarflexion and eversion/inversion range of motion - peak ankle inversion velocity - peak ankle plantarflexion and internal rotation moments - static and dynamic postural balance Muscle activity of: - M. gastrocnemius medialis and lateralis - M. peroneus longus - M. semitendinosus - M. biceps femoris - M. gluteus medius - M. vastus medialis und lateralis Hormonal concentrations of: - FSH - LH - Estrogen - Progesterone - Testosterone - DHEAS-S - Cortisol - 17-H-OP - Prolactin - TSH - AMH primary outcomes will be recorded 8 times (4 times during menstrual cycle, during 2 menstrual cycles) Biomechanical primary outcomes will be recorded using marker-based motion tracking and surface electromyography Hormonal levels will be recorded using blood serum collected using the TAP-Device | — |
Secondary
| Measure | Time frame |
|---|---|
| Influence of biomechanics of functional assessments and hormonal profile on ligamentous lower extremity injuries: participants will be followed longitudinally and in the event of a ligamentous lower extremity injury their data from the primary outcome will be compared to the participants who did not sustain an injury Injury mechanisms of ligamentous lower extremity injuries: after sustaining an injury, all information available on the injury mechanism (interview with participants, observations of bystanders, review of video material if available) will be collected and analyzed | — |
Countries
Switzerland
Contacts
Public ContactEveline Graf
ZHAW Zürcher Hochschule für Angewandte Wissenschaften
Outcome results
None listed