The effect of gut resistome on the development of antimicrobial resistance in Gram-negative urinary tract infection pathogens: a single center cohort study with kidney transplant recipients

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00035027

Enrollment

150

Registered

2024-09-09

Start date

2022-02-05

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Antibiotic resistance development in uropathogenic bacteria

Interventions

Group 1: Kidney transplant recipients: Rectal swab collection Urine sample collection Metagenomic sequencing of rectal swabs Whole genome sequencing of the gram-negative isolates taken from the urine

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Kidney Transplantation

Exclusion criteria

Exclusion criteria: Inflammatory bowel disease

Design outcomes

Primary

Measure	Time frame
Detection of the resistance genes of the Gram-negative uropathogens, isolated from significant bacteriuria (defined as =103 CFU/ml) or UTI, in the gut resistome before the infection or bacteriuria.	—

Secondary

Measure	Time frame
Correlation between the gut resistome and the phenotypic resistance of Gram-negative uropathogens isolated from significant bacteriuria or UTI	—

Countries

Germany

Contacts

Public ContactKaan Kocer

Universitäsklinikum Schleswig-Holstein

kaan.kocer@uni-luebeck.de017631341135

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026