Vascular Effects of Electroconvulsive Therapy: A Neurosonographic Study

Vascular Effects of Electroconvulsive Therapy: A Neurosonographic Study - VEENS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00035002

Enrollment

Registered

2025-02-14

Start date

2025-02-12

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F32.2 F32.3 F33.2 F33.3

Interventions

Group 1: According to case number planning, 35 patients from clinical-care with a diagnosis of depressive disorder and an indication for electroconvulsive therapy (ECT) based on this diagnosis. Neuros

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. ECT prescribed as an inpatient at home 2. written consent for participation in the project 3. indication for ECT is a diagnosis of F32.x (depression) or F33.x (recurrent depression) according to ICD-10.

Exclusion criteria

Exclusion criteria: 1. pregnancy and breastfeeding 2. persons who are accommodated by court or official order and/or receive ECT 3. persons with known cerebral vascular diseases, e.g. stenoses, stents or aneurysms. 4. persons who are incapable of giving consent and/or are unable to understand the nature, significance and scope of the research project and to give their consent 5. persons who are unwilling or unable to understand and follow the instructions of the staff 6. persons without a suitable transcranial window for sonographic assessment of the intracranial vascular status

Design outcomes

Primary

Measure	Time frame
Quantification of the change in flow dynamics before, immediately after and one hour after the seizure during ECT using TCCS in five consecutive ECT sessions. Particular focus is placed on the analysis of intracranial flow profiles.	—

Secondary

Measure	Time frame
Correlation of cerebral perfusion changes with the clinical • the clinical quality criteria of the seizures (heart rate, seizure duration, hemispheric coherence, amplitude and postictal suppression) • the anesthetic used (etomidate, esketamine or propofol) • the electrode positioning • the blood pressure • the etCO2 • the change in the Montgomery-Åsberg Depression Rating Scale (MADRS) and in the Beck Depression Inventory II (BDI-II) (result of the baseline visit - result of the last study visit)	—

Measure

Time frame

Correlation of cerebral perfusion changes with the clinical • the clinical quality criteria of the seizures (heart rate, seizure duration, hemispheric coherence, amplitude and postictal suppression) • the anesthetic used (etomidate, esketamine or propofol) • the electrode positioning • the blood pressure • the etCO2 • the change in the Montgomery-Åsberg Depression Rating Scale (MADRS) and in the Beck Depression Inventory II (BDI-II) (result of the baseline visit - result of the last study visit)

—

Countries

Germany

Contacts

Public ContactRebecca Paetow

Universitätsklinik der RWTH Aachen, Klinik für Psychiatrie, Psychotherapie und Psychosomatik

rpaetow@ukaachen.de+49241 800

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026