Patients undergoing elective surgery with an anticipated duration of at least 180 minutes
Conditions
Interventions
Group 1: Adult Patients undergoing elective surgery with an estimated duration of at least 180 minutes. At predefined measuring timepoints (study inclusion, before surgery after hospital admission, ho
Sponsors
Uniklinik RWTH Achen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Given informed consent 2. Adult patients (= 18 years) 3. Elective major surgery with anticipated duration of > 180 minutes 4. Patients receiving central venous and arterial access as per clinical routine
Exclusion criteria
Exclusion criteria: • Patients < 18 years, pregnant or lactating patients • Patients unable to consent or follow instructions from medical team (cognitive, psychiatric, or severe language barriers) • Medical conditions, surgical and anesthesia-related procedures preventing the intraoperative use of the planned medical devices • Propofol allergy as contraindication for total intravenous anesthesia (TIVA) • Enrolment in an industry sponsored randomized trial within the last 30 days (co-enrolment in academic randomized trials will be considered on a case-by-case basis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Correlation of intraoperative mean arterial pressure (MAP) and resting energy expenditure (REE) 2)Correlation of muscle mass and anesthesia related outcomes | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Laboratory outcomes: Blood gas analyses (longitudinal assessment) Lactate Arteriovenous difference in partial pressures Central venous oxygen saturation 2) Metabolic outcomes (longitudinal assessment): Indirect calorimetry Body composition Perioperative blood glucose and insulin Quadriceps mass and elastography 3) Clinical outcomes Hemodynamics Vasopressor treatment Fluid balance on the day of surgery Perioperative transfusions Mechanical ventilation Complications after surgery until hospital discharge or until 7 days after surgery Hospital-mortality Length of stay 4) Anesthesia related outcomes Duration of mechanical ventilation Dosage of opioids, hypnotics and muscle relaxants Use of antidots for opioids, benzodiazepines and muscle relaxants Intraoperative depth of anesthesia Intraoperative microcirculation Anesthesia related adverse events | — |
Countries
Germany
Contacts
Public ContactAileen Hill
Uniklinik RWTH Aachen
Outcome results
None listed