Multimodal imaging for the evaluation of the gut-brain axis in patients with chronic inflammatory bowel diseases and neurodegenerative and neuroinflammatory diseases

Multimodal imaging for the evaluation of the gut-brain axis in patients with chronic inflammatory bowel diseases and neurodegenerative and neuroinflammatory diseases - Imaging Gut-Brain-Axis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00034986

Enrollment

Registered

2024-08-30

Start date

2024-09-04

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G20

Interventions

Group 1: Patients with manifest Parkinson's disease: Preventive colonoscopy with endomicroscopic imaging of the enteric nervous system (ENS) Collection of clinical scores for constipation (Cleveland c

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1) Clinically proven Parkinson's disease 2) Clinically proven REM sleep behavior disorder 3) Healthy controls without evidence of Parkinson's disease or constipation

Exclusion criteria

Exclusion criteria: Gastrointestinal disease: inflammatory bowel disease, exocrinic pankreas insufficency, cealiac disease, gastrointestinal malignom Pregnant and breestfeeding women

Design outcomes

Primary

Measure	Time frame
Endomicroscopic changes of the ENS at the time of screening colonoscopy	—

Secondary

Measure	Time frame
Endomicroscopic changes of the ENS in correlation with age, disease stage and constipation	—

Countries

Germany

Contacts

Public ContactMark Ellrichmann

Klinik für Innere Medizin I, Interdisziplinäre Endoskopie UKSH, Campus Kiel

mark.ellrichmann@uksh.de0431-500-22371

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026